Originally used to suppress ovulation of female dogs in heat, Mibolerone is one of the most harsh steroids in existence. It is approximately 5.9 times as anabolic, and 2.5 times as androgenic as Testosterone.  Cheque drops provide a short adrenaline-like aggression rush in athletes when used immediately prior to a sporting event.  Due to its high androgenic properties, it is often the cause of progesterone related gynecomastia.

Background

Cheque Drops are manufactured by Upjohn. Mibolerone powder is produced by three Chinese labs currently. A few underground labs produce the compound as well; including Supra, who is currently number one in Cheque Drop production.

Steroid Action

Due to the  short half-life of Mibolerone, it is most commonly used by athletes about 30-40 minutes before their sporting event.  Cheque drops are placed under the athletes tongue, and effects including aggression, strength and adrenaline rush are felt rapidly.  The drug leaves the body with in approximately four hours. 

As well as being one of the most androgenic compounds, mibolerone is also one of the most toxic.   The most common side effect is progesterone related gynecomastia because it is a 19 nor-androgen.    It can also severely affect liver function because it is a 17AA compound.  Use with other 17AA compounds can be extremely damaging to the liver.  If used in low doses (less than 2 weeks), there are very few, if any anabolic effects.  When used short term, natural testosterone will return to normal levels very quickly.  However, if use surpasses 2 weeks there is an extremely high risk for liver damage and natural testosterone suppression because it is an LH blocker. Also, this compound does not convert into estrogen; therefore, progesterone production is increased.

Known side effects of the compound are increased aggression, disturbed sleep patterns or insomnia, high blood pressure and severe liver damage.  It is highly dangerous if used by females.  Some female side effects include severe acne, cessation of the menstrual cycle, deepening of the voice, clitoral enlargement and vaginal secretion.  Effects of the drug will also be passed onto an unborn fetus.

Technical Data

Studies have been difficult to perform due to the known high toxicity levels of the drug, and lack of pragmatic use in humans.  One study in humans indicated potential altered liver function so the study was immediately ceased(1).

In rats, Mibolerone has been shown to be both highly anabolic and androgenic.   It was found to be 41 times more anabolic and 16 times more androgenic than methyltestosterone.  No estrogenic activity in mice was reported when when 1.0 mg per animal per day was administered.  It was also found to be anti-estrogenic in mice 10 mcg or less when subcutaneously tested against estradiol.  A dose of 1,600,000mcg/kg was fatal in 50% of the rats.

User Notes

This is really nasty stuff. Basically, it’s only good for increasing aggression just prior to an athletic event or before an intense training session. For most athletes, Methyltestosterone, Testosterone Suspension, or Halotestin is typically preferred for this purpose because Cheque Drops are rarely found on the black market.

Mibolerone is the chemical name of active ingredient in Cheque Drops. Cheque is a registered trademark of Pharmacia & UpJohn in the United States and/or other countries.